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GAA-creatine in elderly

GAA-creatine in elderly

The objective of this pilot trial was to evaluate the effects of 8-week GAA-creatine supplementation versus placebo on skeletal muscle…

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GAA in urea cycle disorders

GAA in urea cycle disorders

The urea cycle generates arginine that is one of the major precursors for creatine biosynthesis. Here we evaluate levels of…

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Single-cell distribution of GAA synthesis

Single-cell distribution of GAA synthesis

The enzymes AGAT and GAMT function together to synthesize creatine from arginine, glycine, and S-Adenosyl methionine. Deficiency in either enzyme…

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Landmark studies on GAA before 1970s

Guanidinoacetic acid has been investigated for almost 90 years, with the pioneering studies on GAA metabolism and synthesis dates back to early 1930’s. In this section, we have collected and chronologized the most prominent historic studies on GAA from leading journals in the field of science and medicine.