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Physiological roles of GAA and its relationship with arginine

Physiological roles of GAA and its relationship with arginine

The role of guanidinoacetic acid (GAA) and its relationship with arginine was reviewed in order to define a replacement ratio…

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GAA supplementation and nitrogen retention

GAA supplementation and nitrogen retention

Creatine stores high-energy phosphate bonds in muscle and is synthesized in the liver through methylation of guanidinoacetic acid (GAA). Supplementation…

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Urinary GAA significantly altered in ASD

Urinary GAA significantly altered in ASD

Autism spectrum disorder (ASD) is a group of early-onset neurodevelopmental disorders. So far, there is no valid biomarker for the…

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Landmark studies on GAA before 1970s

Guanidinoacetic acid has been investigated for almost 90 years, with the pioneering studies on GAA metabolism and synthesis dates back to early 1930’s. In this section, we have collected and chronologized the most prominent historic studies on GAA from leading journals in the field of science and medicine.