Human skeletal muscle contains no detectable GAA

Human skeletal muscle contains no detectable GAA

We analyzed data from previously completed trials to determine the effects of supplemental guanidinoacetic acid (GAA) on markers of muscle bioenergetics in healthy men using 1.5 T magnetic resonance spectroscopy. No detectable GAA (<0.1 μmol/L) was found in the vastus medialis muscle at baseline nor at follow-up. This implies deficient GAA availability in the human skeletal muscle, suggesting absent or negligible potential for creatine synthesis from GAA inside this tissue, even after GAA loading.

Ostojic SM, Ostojic J. Human skeletal muscle contains no detectable guanidinoacetic acid. Appl Physiol Nutr Metab. 2018;43(6):647-649. doi:10.1139/apnm-2017-0873

Categories: Human Nutrition

Leave a Reply

Your email address will not be published.