Guanidino compounds and hemodialysis
Despite a large number of reports that have appeared recently in regard to guanidino compounds and their role in causing uremia and aggravating renal failure, many points are still unclear. There are very few reports on guanidino compounds in acute renal failure, and those that are available have deficiencies related to the clinical assessment or etiological research. Furthermore, many of the patients admitted to the Intensive Care Unit have renal failure in a high risk situation of multiple organ failure, thus contributing to the difficulty of treatment by dialysis. The clinical picture varies, and can include those with infective foci, decreased immunological capacity, and unstable circulatory and respiratory system, abnormality of the central nervous system, and hepatic failure or disseminated intravascular coagulation. The pathophysiology of acute renal failure was investigated to elucidate the miscellaneous complicating factors by analyzing guanidino compounds in patients requiring hemodialysis.
Ochiai Y, Abe S, Yamada T, Tada K, Kosaka F. Guanidino compounds and hemodialysis. Adv Exp Med Biol. 1982;153:459-64.