GAA protects against lactic acidemia
Increased blood lactic acid is likely to be involved in sudden death syndrome in broiler chicken. Guanidinoacetic acid with direct or indirect influence on the cardiovascular system may provide, to some degree, protection against lactic acidemia in birds. A total number of 144 male broiler chicks (Ross 308) were used in a complete randomised block design to investigate the effects of dietary supplementation of GAA at 0.6, 1.2, 1.8, 2.4 and 3 g/kg on the physiological response of broiler chicks to an acute lactic acidosis in an 8-days experiment. Birds receiving 1.8 and 3 g/kg GAA exhibited lesser mortality percentage compared with the control birds and those received dietary GAA at 0.6 and 1.2 g/kg (p < .03). Dietary inclusion of 1.2 g/kg GAA to broiler chicks increased serum concentration of uric acid compared to the control birds and those received 2.4 g/kg (p < .02). The mean serum concentration of creatinine was greater in the birds receiving different GAA levels compared with the control birds (p < .0001). The serum concentration of nitric oxide decreased in the birds receiving 1.2 g/kg GAA by 21.05 and 15.57% compared with the control birds and those received 1.8 g/kg of GAA, respectively (p < .04). A lesser frequency for liver colour score 5 was observed in the birds fed on the diet with 0.6 g/k GAA (p < .0001). It was concluded that dietary administration of GAA deteriorates the adaptive physiological responses to an acute lactic acidosis in broiler chicken possibly through liver and kidney dysfunction.
Boroumandnia Z, Khosravinia H, Masouri B, Parizadian Kavan B. Effects of dietary supplementation of guanidinoacetic acid on physiological response of broiler chicken exposed to repeated lactic acid injection. Italian Journal of Animal Science. 2021;20(1):153-162.