GAA as a biomarker in schizophrenia

GAA as a biomarker in schizophrenia

GAA (also known as glycocyamine) is a naturally occurring metabolite of glycine and direct metabolic precursor of creatine, a key component of brain energy metabolism and oxidant-antioxidant homeostasis. GAA concentrations in the brain, cerebrospinal fluid, serum, and urine are responsive to various brain conditions, including mental, behavioral and neurodevelopmental disorders. Specifically, GAA appears to be among the most sensible biomarkers of amino-acid metabolism in schizophrenia, with GAA has recently been cataloged in the group of potential metabolite signatures of the disease . Disturbances in GAA balance likely happen due to a GAA role in excess methylation, a well-recognized metabolic component of schizophrenia.

Ostojic SM. Guanidinoacetic acid as an adjunct biomarker in schizophrenia. Asian Journal of Psychiatry, 2021. DOI: 10.1016/j.ajp.2021.102566.

Categories: Pathophysiology

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