GAA and analogues affect mammalian cerebral cortex

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• August 15, 1961
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Recently, the neuropharmacological action of gama-guanidinobutyric acid, a biochemical constituent of the brain has interested some workers. Purpura et al investigated the effects of guanidinoacids on evoked potentials of themammalian cerebral cortex. Their effects on the crayfish stretch receptor cellwere investigated by Edwards and Kuffler. In the previous paper, the authors investigated the effects of some guanidino-derivatives on the isolated guinea-pig ileum and blood pressure of the rabbit andcat. In the investigation, we compared their effects with those of omega-aminoacids.In the present study, we have observed their effects on evoked potentials of themammalian cerebral cortex. [TRUNCATED]

Takahashi H, Arai B, Koshino C. Effects of guanidinoacetic acid, gamma-guanidinobutyric acid and gamma-guanidinobutyryl-methylester on the mammalian cerebral cortex. Jpn J Physiol. 1961 Aug 15;11:403-9.