Creatine-GAA metabolism in vitamin E deficiency
As is well known, many animals, when deprived of vitamin E (alpha-tocopherol), develop a paralysis of the voluntary muscles. The partly grown rabbit becomes completely helpless in 3 to 4 weeks. The progress of the disease is characterized by histological changes and alterations in chemical composition. Thus muscle creatine declines considerably, in rats even before any abnormality in structure is evident. There is a marked increase in urinary creatine, which may ultimately be 5ts much w 30-fold the usual excretion. Since muscle loses little more than half its normal creatine content, the rate of creatine synthesis must be increased.