Cellular bioenergetics of GAA and mitochondria

Cellular bioenergetics of GAA and mitochondria

Guanidinoacetic acid (GAA) is a natural precursor of creatine, and a possible substrate for the creatine kinase (CK) enzyme system, serving as a creatine mimetic. Its direct role in cellular bioenergetics has been confirmed in several studies, however GAA utilization by CK seems to be a second-rate as compared to creatine, and compartment-dependent. Here we discuss various factors that might affect GAA use in high-energy phosphoryl transfer in the cytosol and mitochondria.

Ostojic SM. Cellular bioenergetics of guanidinoacetic acid: the role of mitochondria. J Bioenerg Biomembr. 2015 Oct;47(5):369-72. doi: 10.1007/s10863-015-9619-7. Epub 2015 Aug 9. PMID: 26255041.

Categories: Reviews

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