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Creatine, α-N-methyl-guanidino-acetic acid, plays a fundamental role in the storage and regeneration of high-energy phosphate in the brain. Defects in the creatine transporter gene (CRT/SLC6A8) result in a significant reduction in brain creatine levels and severe neurological symptoms such as intellectual disability. Clarifying creatine dynamics in the brain is essential to increase our understanding of […]

Guanidinoacetic acid, the immediate precursor of creatine, is gaining renewed attention as a nutritional and therapeutic agent capable of enhancing tissue bioenergetics. Yet, a comprehensive mechanistic framework describing how exogenous guanidinoacetic acid is processed in the human body is lacking. This concept paper proposes an integrated metabolic model of guanidinoacetic acid utilization, synthesizing available kinetic […]

Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of guanidinoacetic acid (GAA) and its preparation (GuanAMINO®) as zootechnical additives for chickens for fattening, chickens reared for laying, chickens reared for reproduction, turkeys for fattening, turkeys reared for reproduction. The FEEDAP Panel concluded that […]

Guanidinoacetic acid (GAA) is immediate substrate for biosynthesis of creatine (CREA). Aside from improving energy utilisation, GAA possesses several features which further enhance its value as a feed additive for poultry. The feed supplement has good thermal stabi lity, which allows it to be safely used in pelleted diets. GAA has high bioavailability, is cost-effective, […]

Guanidinoacetic acid (GAA) is a nutrient that has been used in human nutrition since the early 1950s. Recommended for its role in creatine biosynthesis, GAA demonstrated beneficial energy-boosting effects in various clinical conditions. Dietary GAA has also been suggested to trigger several creatine-independent mechanisms. Besides acting as a direct precursor of high-energy phosphagen creatine, dietary […]

Creatine is an amino acid derivate commonly found in vertebrate muscle tissue. Creatine facilitates the recycling of adenosine triphosphate and thus contributes to the energy supply of the muscles as well as the brain. Creatine is used as a supplement for several reasons and its effects in humans, particularly in sports medicine, have been studied […]

Guanidinoacetic acid (GAA) is a natural amino acid derivative that is well-recognized for its central role in the biosynthesis of creatine, an essential compound involved in cellular energy metabolism. GAA (also known as glycocyamine or betacyamine) has been investigated as an energy-boosting dietary supplement in humans for more than 70 years. GAA is suggested to […]

Guanidinoacetic acid is the direct precursor of creatine and its phosphorylated derivative phosphocreatine in the body. It is a safe nutritional supplement that can be used to promote muscle growth and development. Improving the growth performance of livestock and poultry and meat quality is the eternal goal of the animal husbandry, and it is also […]

The role of guanidinoacetic acid (GAA) and its relationship with arginine was reviewed in order to define a replacement ratio between GAA and arginine for broiler diet formulation, the ratio being of how much arginine could be spared, or replaced by GAA. Guanidionoacetic acid, the precursor of creatine, can be synthesized de novo from the […]

Guanidinoacetic acid (GAA, also known as glycocyamine or betacyamine) is a naturally-occurring derivative of glycine and a direct metabolic precursor of creatine, a key player in high-phosphate cellular bioenergetics. GAA is found in human serum and urine, with circulating GAA likely reflects an equilibrium between its endogenous production and utilization/excretion. GAA deficiency (as indicated by […]