Guanidinoacetic acid (GAA) accumulates in the genetic deficiency of the GAMT enzyme and it is believed to cause the seizures that often occur in this condition. However, evidence that it is indeed epileptogenic is scarce and we previously found that it does not cause neuronal hyperexcitation in in vitro brain slices. Here, we used Micro-Electrode […]
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GAA is not epileptogenic
- January 3, 2023
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