Creatine-GAA metabolism in vitamin E deficiency

As is well known, many animals, when deprived of vitamin E (alpha-tocopherol), develop a paralysis of the voluntary muscles. The partly grown rabbit becomes completely helpless in 3 to 4 weeks. The progress of the disease is characterized by histological changes and alterations in chemical composition. Thus muscle creatine declines considerably, in rats even before […]

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GAA, CR and CRN in children with nephrotic syndrome

The pathogenesis of the nephrotic syndrome is not entirely clear.The alterations in the electrophoretic pattern of the serum and its albumin fractions in nephrotic patients, along with changes in the esterase activity of their plasma, have focused attention on the liver as the source of these modifications. These reports, however, have not been conclusive. [TRUNCATED] […]

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GAA elimination in patients with myasthenia gravis

From the amount of glycocyamine eliminated (before and after overloading the body with glycine) there is no evidence of any defect in transamidination and transmethylation processes in patients with myasthenia gravis. Torda C, Wolff HG. Glycocyamine elimination in patients with myasthenia gravis. J Lab Clin Med. 1946 Nov;31(11):1174-8. PMID: 20274102.

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