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Some guanidino compounds are known to be convulsants and to change in the brain during seizures. In this study, we examined the serum levels of guanidino compounds in healthy adults (controls), non-epileptic neurological patients (NENP) and epileptic neurological patients (ENP). In healthy adults, serum levels of guanidinoacetic acid (GAA), creatinine (CRN) and homoarginine (HArg) were […]

The present study was undertaken to investigate the changes of plasma and urinary levels of guanidinoacetic acid (GAA) in relation to the alteration of renal activity of glycine amidinotransferase (GAT) in the acute stage of renal failure. Rats received cephaloridine at doses of 0 (control), 100 and 1000 mg/kg body weight. The 100 mg/kg group […]

This study was undertaken to evaluate the relation between the urinary excretion of guanidinoacetic acid (GAA) and other substances in hypertensive patients (6 with borderline hypertension and 29 with hypertension) and 12 normal controls. In 10 of the hypertensive patients, GAA was measured before and after 4 weeks of treatment with calcium entry blocker. In […]

In order to investigate the guanidinoacetic acid (GAA) metabolism in uremia, we have measured serum guanidino compounds in patients with chronic renal failure (CRF) in comparison with normal subjects, and the renal content of GAA and glycine amidinotransferase (GAT) activity in the kidney of experimental CRF rabbits. Serum concentrations of guanidinosuccinic acid (GSA) and methylguanidine […]

The patients studied are three sisters affected with hyperargininemia. The clinical and biochemical picture has been reported in full. Like all patients affected with urea cycle diseases, the first clinical symptoms seen in a patient with hyperargininemia are irritability, coma and epilepsy. All the patients described either by us or in the literature are still […]

Despite a large number of reports that have appeared recently in regard to guanidino compounds and their role in causing uremia and aggravating renal failure, many points are still unclear. There are very few reports on guanidino compounds in acute renal failure, and those that are available have deficiencies related to the clinical assessment or […]

Patients with gyrate atrophy of the choroid and retina have 10- to 20-fold increased ornithine concentrations in body fluids and significantly reduced activity of ornithine aminotransferase in lymphocytes and cultured fibroblasts. We administered intravenous arginine to six patients and six controls to study in vivo inhibition by high ornithine concentrations of arginine-glycine transamidinase, the rate-limiting […]