Methyl donors and GAA balance serum homocysteine

Guanidinoacetic acid (GAA) is the natural biosynthetic precursor of creatine, in a metabolic reaction that requires only a methyl group transfer. The use of GAA as a food additive for restoring creatine load in human tissues is rather unexplored and data on efficacy and safety are limited. In particular, an increase in serum homocysteine after […]

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Safety profiles after six-week GAA intake

Guanidinoacetic acid (GAA) is a natural precursor of creatine, yet the potential use of GAA as a nutritional additive for restoring creatine availability in humans has been limited by unclear efficacy and safety after exogenous GAA administration. The present study evaluated the effects of orally administered GAA on serum and urinary GAA, creatine and creatinine […]

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Clinical study of GAA and betaine in arthritis

Twenty-two patients with arthritis received 5 gm of glycocyamine and 20.16 gm of betaine by mouth daily, in hospital and after discharge, for periods ranging from 13 to 42 days. A control group of 22 patients, indistinguishable from the treated group, were maintained on the same regimen and given placebos resembling the agents under study. […]

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