Guanidinoacetic acid (GAA) is an intermediate in the biosynthesis of creatine (Cr), yet its use in human nutrition is limited due to a lack of a clear understanding of its’ dose-response effect. Thus, the purpose of this study was to investigate the effect of three different dosages of GAA (1.2, 2.4 and 4.8 g/day) administered […]
Read More
Creatine is essential for normal neural development; children with inborn errors of creatine synthesis or transport exhibit neurological symptoms such as mental retardation, speech delay and epilepsy. Creatine accretion may occur through dietary intake or de novo creatine synthesis. The objective of the present study was to determine how much creatine an infant must synthesise […]
Read More
Guanidinoacetic acid (GAA) is the natural biosynthetic precursor of creatine, in a metabolic reaction that requires only a methyl group transfer. The use of GAA as a food additive for restoring creatine load in human tissues is rather unexplored and data on efficacy and safety are limited. In particular, an increase in serum homocysteine after […]
Read More
Guanidinoacetic acid (GAA) is a natural precursor of creatine, yet the potential use of GAA as a nutritional additive for restoring creatine availability in humans has been limited by unclear efficacy and safety after exogenous GAA administration. The present study evaluated the effects of orally administered GAA on serum and urinary GAA, creatine and creatinine […]
Read MoreNo abstract available. Aldes JH. Glycocyamine betaine as an adjunct in the treatment of neuromuscular disease patients. J Ark Med Soc. 1957;54(5):186-194.
Read MoreNo abstract available. Liversedge LA. Glycocyamine and betaine in motor-neurone disease. Lancet. 1956;271(6953):1136-1138. doi: 10.1016/s0140-6736(56)90154-4
Read MoreNo abstract available. Billig HE Jr, Morehouse LE. Performance and metabolic alterations during betaine glycocyamine feeding in myasthenia gravis. Arch Phys Med Rehabil. 1955;36(4):233-236.
Read MoreNo abstract available. Basom WC, Breck LW, Leonard MH. The effect of betaine and glycocyamine in the management of chronic anterior poliomyelitis. Int Rec Med Gen Pract Clin. 1955;168(2):70-71.
Read MoreNo abstract available. Watkins AL. Betaine and glycocyamine in the treatment of poliomyelitis. N Engl J Med. 1953;248(15):621-623. doi:10.1056/NEJM195304092481501
Read MoreNo abstract available. Fallis BD, Lam RL. Betaine and glycocyamine therapy for the chronic residuals of poliomyelitis. J Am Med Assoc. 1952;150(9):851-853. doi: 10.1001/jama.1952.03680090015007
Read More