Guanidinoacetic acid (GAA) is the natural biosynthetic precursor of creatine, in a metabolic reaction that requires only a methyl group transfer. The use of GAA as a food additive for restoring creatine load in human tissues is rather unexplored and data on efficacy and safety are limited. In particular, an increase in serum homocysteine after […]
Read More
Guanidinoacetic acid (GAA) is a natural precursor of creatine, yet the potential use of GAA as a nutritional additive for restoring creatine availability in humans has been limited by unclear efficacy and safety after exogenous GAA administration. The present study evaluated the effects of orally administered GAA on serum and urinary GAA, creatine and creatinine […]
Read MoreNo abstract available. Aldes JH. Glycocyamine betaine as an adjunct in the treatment of neuromuscular disease patients. J Ark Med Soc. 1957;54(5):186-194.
Read MoreNo abstract available. Liversedge LA. Glycocyamine and betaine in motor-neurone disease. Lancet. 1956;271(6953):1136-1138. doi: 10.1016/s0140-6736(56)90154-4
Read MoreNo abstract available. Billig HE Jr, Morehouse LE. Performance and metabolic alterations during betaine glycocyamine feeding in myasthenia gravis. Arch Phys Med Rehabil. 1955;36(4):233-236.
Read MoreNo abstract available. Basom WC, Breck LW, Leonard MH. The effect of betaine and glycocyamine in the management of chronic anterior poliomyelitis. Int Rec Med Gen Pract Clin. 1955;168(2):70-71.
Read MoreNo abstract available. Watkins AL. Betaine and glycocyamine in the treatment of poliomyelitis. N Engl J Med. 1953;248(15):621-623. doi:10.1056/NEJM195304092481501
Read MoreNo abstract available. Fallis BD, Lam RL. Betaine and glycocyamine therapy for the chronic residuals of poliomyelitis. J Am Med Assoc. 1952;150(9):851-853. doi: 10.1001/jama.1952.03680090015007
Read MoreNo abstract available. Borsook ME, Billig HK, Golseth JG. Betaine and glycocyamine in the treatment of disability resulting from acute anterior poliomyelitis. Ann West Med Surg. 1952;6(7):423-427.
Read More
Twenty-two patients with arthritis received 5 gm of glycocyamine and 20.16 gm of betaine by mouth daily, in hospital and after discharge, for periods ranging from 13 to 42 days. A control group of 22 patients, indistinguishable from the treated group, were maintained on the same regimen and given placebos resembling the agents under study. […]
Read More