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Several preliminary studies suggest dietary guanidinoacetic acid (GAA) might impact methyl group availability and/or methylation biomarkers, fueling ongoing debates. This study aimed to explore the relationship between dietary GAA intake and plasma indicators of the methylation cycle in individuals aged one year and older, using data from the 2001-2002 National Health and Nutrition Examination Survey […]

A post-marketing surveillance study assessed the adverse events and possible risk of elevated homocysteine levels after the supplementation with creatine-guanidinoacetic acid mixture in apparently healthy adults. The participants were recruited through social media platforms and online discussion boards, with side effects and total plasma homocysteine (T-Hcy) levels evaluated regularly during a supplementation period of 6 […]

The main objective of this pilot study was to compare the effects of short-term supplementation with a mixture containing creatine and guanidinoacetic acid (GAA) versus creatine alone on body composition indices in men and women. Twenty-three apparently healthy young adults (mean age: 21.4 ± 0.6 years; 10 females) were randomly assigned to receive either a […]

The authors studied the effects of 24-h fasting on serum levels of GAA, creatine, and creatinine in 24 non-vegetarian healthy adults. Blood was taken before and following an intervention, with levels corrected for fasting-induced changes in plasma volume. Food abstention induced a significant decrease in serum GAA by 39.5% (p < 0.001), while creatinine levels increased by […]

The authors analyzed forms of creatine for sale on Amazon.com and evaluated if the advertised claims are supported by the available scientific evidence, and analyzed the cost per gram of the forms of creatine. A total of 175 creatine supplements were included and the authors reported the total creatine content per serving, form(s) of creatine […]

Tackling impaired bioenergetics in multiple sclerosis (MS) has been recently recognized as an innovative approach with therapeutic potential. GAA is an experimental nutrient that plays a significant role in high-energy phosphate metabolism. The preliminary trials suggest beneficial effects of supplemental GAA in MS, with GAA augments biomarkers of brain energy metabolism and improves patient-reported features […]

Guanidinoacetic acid (GAA) is a natural amino acid derivative involved in several metabolic pathways across the human body, including creatine biosynthesis, arginine utilization, and neuromodulation. Apart from GAA synthesized internally from glycine and arginine, a total daily exposure to GAA also involves exogenous dietary sources. However, a majority of food databases provide no comprehensive data […]

Guanidinoacetic acid (GAA; also known as glycocyamine) is a natural amino acid-like derivative of glycine and L-arginine. GAA plays several metabolic roles in the human body, with creatine synthesis being recognized as a crucial pathway of GAA utilization. A daily output of GAA largely depends on endogenous synthesis that occurs mainly in the kidney and […]

The objective of this pilot trial was to evaluate the effects of 8-week GAA-creatine supplementation versus placebo on skeletal muscle and brain creatine levels, cognitive function, functional outcomes, and safety biomarkers in men and women aged 65 years and older. Twenty-one healthy elderly individuals (age 69.6 ± 4.9 years, body mass index 27.6 ± 4.2 […]

Dietary guanidinoacetic acid (GAA) has been suggested to be advantageous for favorable changes in tissue bioenergetics in terms of responder versus nonresponder performance, yet no studies so far explored the proportion of two distinct populations following short-term GAA intervention. A secondary analysis of previously completed guanidinoacetic acid (GAA) trials has been carried out in aim […]