The synthesis of creatine from guanidinoacetic acid in liver was originally demonstrated by Borsook & Dubnoff, and these authors later concluded that guanidinoacetic acid was not a normal constituent of that organ. This conclusion was confirmed by Bodansky, Duff & McKinney, who reported that no guanidinoacetic acid could be detected in normal animals. [TRUNCATED]. Rosenberg […]
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As is well known, many animals, when deprived of vitamin E (alpha-tocopherol), develop a paralysis of the voluntary muscles. The partly grown rabbit becomes completely helpless in 3 to 4 weeks. The progress of the disease is characterized by histological changes and alterations in chemical composition. Thus muscle creatine declines considerably, in rats even before […]
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The pathogenesis of the nephrotic syndrome is not entirely clear.The alterations in the electrophoretic pattern of the serum and its albumin fractions in nephrotic patients, along with changes in the esterase activity of their plasma, have focused attention on the liver as the source of these modifications. These reports, however, have not been conclusive. [TRUNCATED] […]
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The purpose of this report is to record the quantitative urinary excretion of glycocyamine, creatine and total creatinine by a group of normal infants and children. Flood RG, Pinelli RW. Urinary glycocyamine, creatine and creatinine; their excretion by normal infants and children. Am J Dis Child. 1949 Jun;77(6):740-5.
Read MoreNo abstract available. Hoberman HD, Lloyd CW, Williams RH. The Role of the Liver in Guanidoacetic Acid Metabolism in Man. Science. 1946 Dec 27;104(2713):619-20.
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From the amount of glycocyamine eliminated (before and after overloading the body with glycine) there is no evidence of any defect in transamidination and transmethylation processes in patients with myasthenia gravis. Torda C, Wolff HG. Glycocyamine elimination in patients with myasthenia gravis. J Lab Clin Med. 1946 Nov;31(11):1174-8. PMID: 20274102.
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The diminished excretion of creatinine in progressive muscular dystrophy is a more striking and specific phenomenon than the excess excretion of creatine, marked though this is. While creatinuria is invariably encountered in all cases of long-standing dystrophy, the extent to which the excretion of creatinine is decreased provides a more reliable indication of the severity […]
Read MoreNo abstract available. Borsook H, Dubnoff JW. The synthesis of glycocyamine in rat kidney and a mechanism of creatine synthesis in vivo. Science. 1940 Jun 7;91(2371):551-2.
Read MoreNo abstract available. Davenport HW, Fisher RB, Wilhelmi AE. The metabolism of creatine: The role of glycocyamine in creatine synthesis. Biochem J. 1938 Feb;32(2):262-70.
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