Creatine, α-N-methyl-guanidino-acetic acid, plays a fundamental role in the storage and regeneration of high-energy phosphate in the brain. Defects in the creatine transporter gene (CRT/SLC6A8) result in a significant reduction in brain creatine levels and severe neurological symptoms such as intellectual disability. Clarifying creatine dynamics in the brain is essential to increase our understanding of […]
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The effects of three metabolizable energy (ME) levels and the use of guanidinoacetic acid (GAA) were evaluated on broiler performance and nutrient digestibility from 1 to 35 d of age. In total, 1944-d-old Ross AP95 male broilers were randomly distributed to six treatments (12 replicates/treatment). Diets were formulated to contain three ME levels (standard energy […]
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The objective of this study was to assess whether maternal guanidinoacetic acid (GAA) supplementation, with or without rumen-protected methionine (RP-Met), during late gestation affects performance, uteroplacental vascular indicators, and metabolic responses in beef cows. From gestation day 202 until parturition, thirty-six pregnant Nellore cows (502 ± 12.8 kg), each carrying a female fetus, were assigned in […]
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Guanidinoacetic acid, the immediate precursor of creatine, is gaining renewed attention as a nutritional and therapeutic agent capable of enhancing tissue bioenergetics. Yet, a comprehensive mechanistic framework describing how exogenous guanidinoacetic acid is processed in the human body is lacking. This concept paper proposes an integrated metabolic model of guanidinoacetic acid utilization, synthesizing available kinetic […]
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Metabolic dysfunction-associated steatotic liver disease (MASLD) remains a prevalent condition with limited diagnostic and therapeutic options. This study aims to identify metabolic signatures of disease progression and develop non-invasive diagnostic models through three independent cohorts (including two cohorts confirmed by biopsy and one cohort confirmed by ultrasound) involving 293 participants for detecting significant fibrosis (≥F2) […]
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Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of guanidinoacetic acid (GAA) and its preparation (GuanAMINO®) as zootechnical additives for chickens for fattening, chickens reared for laying, chickens reared for reproduction, turkeys for fattening, turkeys reared for reproduction. The FEEDAP Panel concluded that […]
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The objective of this study was to evaluate the hepatic metabolism and performance of broilers fed reduced-energy diets (50 kcal/kg less), with or without guanidinoacetic acid (GAA). A total of 432-day-old male chicks of the Cobb 500 lineage were distributed in a completely randomized design with three treatments and eight replications. The treatments consisted of […]
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Arginase 1 deficiency (ARG1-D) is an autosomal recessive urea cycle disorder characterised by chronic hyperargininaemia, progressive spasticity, loss of mobility, and cognitive dysfunction. Standard of care (SOC), based on dietary protein restriction, rarely prevents progression. Pegzilarginase, a recombinant human enzyme, is the first approved disease-modifying therapy. We report outcomes from Study 102A (n = 14; up to […]
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Guanidinoacetic acid (GAA) is the precursor to creatine. Preliminary studies indicate that GAA supplementation (e.g. 2–3 g/d for 4 weeks) can increase brain creatine to a similar degree as higher amounts of CrM. However, more research is needed to assess the efficacy of long-term higher-dose CrM supplementation on cognitive function and whether GAA may provide similar or […]
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Guanidinoacetic acid (GAA) is the direct precursor of creatine and is often used as a creatine source in feed. Due to the limitation of creatine synthesis in the body, supplementation of GAA to the diet may lead to higher creatine concentrations in sows’ milk which potentially enhance piglet growth and reduce piglet mortality. In addition, […]
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