The objective of this study was to evaluate the hepatic metabolism and performance of broilers fed reduced-energy diets (50 kcal/kg less), with or without guanidinoacetic acid (GAA). A total of 432-day-old male chicks of the Cobb 500 lineage were distributed in a completely randomized design with three treatments and eight replications. The treatments consisted of […]
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Arginase 1 deficiency (ARG1-D) is an autosomal recessive urea cycle disorder characterised by chronic hyperargininaemia, progressive spasticity, loss of mobility, and cognitive dysfunction. Standard of care (SOC), based on dietary protein restriction, rarely prevents progression. Pegzilarginase, a recombinant human enzyme, is the first approved disease-modifying therapy. We report outcomes from Study 102A (n = 14; up to […]
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Guanidinoacetic acid (GAA) is the precursor to creatine. Preliminary studies indicate that GAA supplementation (e.g. 2–3 g/d for 4 weeks) can increase brain creatine to a similar degree as higher amounts of CrM. However, more research is needed to assess the efficacy of long-term higher-dose CrM supplementation on cognitive function and whether GAA may provide similar or […]
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Guanidinoacetic acid (GAA) is the direct precursor of creatine and is often used as a creatine source in feed. Due to the limitation of creatine synthesis in the body, supplementation of GAA to the diet may lead to higher creatine concentrations in sows’ milk which potentially enhance piglet growth and reduce piglet mortality. In addition, […]
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This study investigated the effects of dietary guanidinoacetic acid (GAA) supplementation on growth performance, carcass traits, meat quality, intestinal morphology, and cecal microbiota composition in yellow-feathered broilers. A total of 360 one-day-old chicks were randomly assigned to five groups with diets containing 0 (control), 300 mg/kg, 600 mg/kg, 900 mg/kg, and 1200 mg/kg GAA. In […]
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Guanidinoacetic acid (GAA) is a direct precursor for creatine synthesis in animals. Because of its great biological value and chemical stability, it can be used as a feed ingredient. The aim of this study was to investigate the effects of GAA on the growth performance, serum biochemical indices and metabolites, intestinal morphology, and intestinal flora […]
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Subtle biological changes related to frailty may be undetected by standard clinical methods, and reliable biomarkers for frailty are still under investigation. This study was conducted to profile plasma metabolite patterns associated with frailty and validate the most significant metabolite for identifying and predicting frailty in cross-sectional and longitudinal analyses. The “Fujian Prospective Aging Cohort” […]
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We investigated the influences of dietary rumen-protected guanidinoacetic acid (RPGAA) on the growth, slaughter performance, and meat quality characteristics of Simmental bulls. In this study, 56 bulls (615 ± 8.9 kg) were randomly assigned to 74-day treatment in four group: control, low-RPGAA (0.3 g/kg dry matter [DM]-guanidinoacetic acid [GAA]), medium-RPGAA (0.6 g/kg DM-GAA), and high-RPGAA (0.9 g/kg DM-GAA), with 14 bulls […]
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This study evaluated the effects of dietary supplementation with guanidinoacetic acid (GAA) and zilpaterol hydrochloride (ZLH) on productive performance, carcass traits, and blood chemistry in non-castrated male lambs over 60 days. Twenty-four Pelibuey × Dorper crossbred lambs (16.3 ± 2.7 kg) were adapted to housing and diet for 14 days before being randomly assigned to […]
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This study evaluated the effects of guanidinoacetic acid (GAA) supplementation during the growing and finishing phases on Nellore bulls’ performance, carcass traits, and meat quality. Fifty-two Nellore bulls were randomly assigned to four treatments: control (CON, without GAA) and three GAA levels (3, 6, and 9 g/kg dry matter [DM] in the growing supplement; 0.3, […]
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