Hepatic metabolism of GAA
The objective of this study was to evaluate the hepatic metabolism and performance of broilers fed reduced-energy diets (50…
GAA after pegzilarginase treatment in ARG1-D
Arginase 1 deficiency (ARG1-D) is an autosomal recessive urea cycle disorder characterised by chronic hyperargininaemia, progressive spasticity, loss of…
Safety of GAA plus creatine
Guanidinoacetic acid (GAA) is the precursor to creatine. Preliminary studies indicate that GAA supplementation (e.g. 2–3 g/d for 4 weeks) can…
GAA for reproductive performance of sows
Guanidinoacetic acid (GAA) is the direct precursor of creatine and is often used as a creatine source in feed.…
About GAA Science
Physiological roles of GAA
GAA could affect many aspects of human metabolism, including cellular bioenergetics, neuromodulation, or oxidant-antioxidant status.
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GAA Fundamentals
Guanidinoacetic acid (also known as glycocyamine or betacyamine) is a normal constituent of human blood, urine, and breast milk.
Being a natural amino acid derivative and a metabolite in the urea cycle, GAA also appears as an intermediate in metabolic pathways of several amino acids, including glycine, serine and arginine. GAA is direct precursor of creatine, a key substrate for cellular energy.
- CAS Registry # 362-97-6
- PubChem CID 763
- Chemical formula C3H7N3O2
- Molar mass 117.1 g/mol
The natural daily turnover of GAA is balanced between endogenous production and kidney excretion; only a minimal amount of GAA is available from food sources (e.g. 10 mg of GAA per kg of meat).
Dr. Sergej Ostojic
GAA-science.com was created and administered by a research group headed by Sergej M. Ostojic, MD, PhD, Professor of Nutrition at the University of Agder and the University of Pécs, who has been involved in GAA research for over a decade.
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