GAA during late gestation
The objective of this study was to assess whether maternal guanidinoacetic acid (GAA) supplementation, with or without rumen-protected methionine…
Modeling GAA supplementation
Guanidinoacetic acid, the immediate precursor of creatine, is gaining renewed attention as a nutritional and therapeutic agent capable of…
GAA treatment for steatotic liver disease
Metabolic dysfunction-associated steatotic liver disease (MASLD) remains a prevalent condition with limited diagnostic and therapeutic options. This study aims…
EFSA on GAA safety and efficacy
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and…
About GAA Science
Physiological roles of GAA
GAA could affect many aspects of human metabolism, including cellular bioenergetics, neuromodulation, or oxidant-antioxidant status.
Latest events
23rd European Symposium on Poultry Nutrition (ESPN 2023)
CCDS Virtual Conference
6th EAAP International Symposium on Energy and Protein Metabolism and Nutrition
GAA Fundamentals
Guanidinoacetic acid (also known as glycocyamine or betacyamine) is a normal constituent of human blood, urine, and breast milk.
Being a natural amino acid derivative and a metabolite in the urea cycle, GAA also appears as an intermediate in metabolic pathways of several amino acids, including glycine, serine and arginine. GAA is direct precursor of creatine, a key substrate for cellular energy.
- CAS Registry # 362-97-6
- PubChem CID 763
- Chemical formula C3H7N3O2
- Molar mass 117.1 g/mol
The natural daily turnover of GAA is balanced between endogenous production and kidney excretion; only a minimal amount of GAA is available from food sources (e.g. 10 mg of GAA per kg of meat).
Dr. Sergej Ostojic
GAA-science.com was created and administered by a research group headed by Sergej M. Ostojic, MD, PhD, Professor of Nutrition at the University of Agder and the University of Pécs, who has been involved in GAA research for over a decade.
Golden Legacy Articles
